Abstract
1. Tissue culture techniques have been applied in many studies on factors influencing the growth of animal viruses. 2. Results with various substances which inhibit influenza virus in tissue cultures are summarized and possible modes of action considered. The effects under consideration are reversible and do not result from death of the tissue or inactivation of the virus. 3. Studies on the mode of action of aromatic diamidines on influenza virus are presented-in some detail. 4. Dinitrophenol, a substance which uncouples phosphorylation from oxidation temporarily interferes with the growth of influenza virus in chorioallantoic membrane tissue without affecting respiration. 5. Growth of influenza virus was found to be dependent on depletable substances in tissue and on glucose in the medium. The latter could be partially replaced by pyruvate. 6. The possible dependence of virus growth on readily available sources of energy and on transfer of energy by phosphorylation is discussed. Interference with synthesis of high energy phosphate by the host cell is considered as an explanation of the local inhibition of viral growth by a variety of substances.
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