Observation of the curative effect between Nocardia rubra cell wall skeleton-injection combined with the intrapleural chemotherapy and following the intrapleural chemotherapy

Abstract

To observe and compare the curative effect between the intrapleural-chemotherapy combined Nocardia rubra cell wall skeleton-injection and the Nocardia rubra cell wall skeleton-injection after control of the malignant pleural effusion by chemotherapy. Every time after elimination of pleural effusion, we injected DDP and Nocardia rubra cell wall skeleton at the same time into pleural cavity; or after we emplaced an improved central vena catheter into pleural cavity then took out closed-drainage or eliminated the pleural effusion every day, then injected 5-FU 0.5 qd intrapleural-space. After the malignant pleural effusion had being controlled, 800 μg Nocardia rubra cell wall skeleton was injected intrapleural-space. (We call it as “improved following-therapy”). Using the improved following-therapy, the control rate of malignant pleural effusion increased: CR + PR, 79.07% > 65.79% (P < 0.05), and the incidence rate of the encapsulated pleural effusion that would impact on patient’s respiratory faction decreased. Conclusion: Giving chemotherapy after closed-drainage or immediately after taking out pleural effusion everyday, then giving biotherapy after pleural effusion had been controlled, the curative effect would be enhanced and the side-reaction would be reduced.