Abstract

Objective To investigate the peripapillary retinal nerve fiber layer (RNFL) thickness,changes in full-field flash electroretinogram (ERG) and their relationship in patients of without obvious diabetic retinopathy (non-diabetic retinopathy,the NDR),light and moderate non-proliferative diabetic retinopathy (NPDR).Methods In our hospital census type 2 diabetes and 128 cases (256eyes),according to the inspection results in accordance with the diabetic retinopathy international staging divided into the NDR group and light,moderate NPDR groups,select age-matched normal subjects 38 cases (76 eyes) as a control group,all subjects mydriasis large line of full-field ERG to determine retinal function using optical coherence tomography (OCT) peripapillary RNFL thickness scanning.Results Compared with the control group,in dark adaptation 3.0,DM groups oscillator potential reaction,b-wave amplitude of light and moderate NPDR group,a-wave amplitude of moderate NPDR group and the b-wave amplitude of moderate NPDR group in light adaptation decreased (P ＜0.05),The incubation period of light,dark adaptation 3.0 b-wave in each group and dark adaptation 3.0 a-wave in light and moderate NPDR group were delay (P ＜0.05); The RNFL thickness in the DM patients than in the normal control group were thinner,compared with the normal control group,the difference of superior in the NDR group,superior and inferior in light NPDR group,every quadrant and the mean RNFL thickncss around the optic disc in moderate NPDR group was statistically significant (P ＜0.05).Conclusions With the increase in the degree of retinopathy in patients with DM,impaired retinal function gradually worsen,the RNFL thickness around the optic disc gradually reduce,ERG and OCT combination of both,quantitative detection of changes in RNFL thickness and prognosis to determine retinal function to provide a reliable means of detection. Key words: Diabetes; Retinal nerve fiber layer thickness; Optical coherence tomography; Full-field flash ERG Figure

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