Abstract
Purpose/Objective: The development of in vivo EPR oximetry now makes it feasible to follow the time course of oxygenation in tumors non-invasively, continuously, and repeatedly. In principle this should be very valuable because radiation response of hypoxic tumors is very sensitive to the level of oxygen and tumor growth, radiation therapy, and chemotherapy all potentially can change tumor pO2 dynamically. Using EPR continuously to follow early post-irradiation changes in RIF-1 tumors receiving fractionated radiation, we observed a previously unobserved transient increase in tumor oxygenation during the first hour.
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