Observation of immunological changes during clinical cycles of skin leishmaniosis

Abstract

In this article, statistics were obtained from patients with cutaneous leishmaniasis, with particular emphasis on the specific course of clinical cycles and immunological changes. Immunological changes showed a decrease in lymphocytes, a significant increase in IgA, IgM, IgG and CIC. These indicators help patients choose the right treatment. The papillae were covered with a whitish coating, and when pressed, a serous-purulent fluid was released. In patients with a disease duration of more than 2 months, the ulcers, almost completely cleared of necrotic masses, were covered with islands of granulations like pomegranate seeds. To assess the state of cytokine indices in patients with cutaneous leishmaniasis, we studied the indices of the anti-inflammatory cytokine IL-4 and the pro-inflammatory cytokine IL-8 and TNF-a, as well as gamma-interferons. In some patients, the infiltrate was quite pronounced, rising above the ulcer in the form of a roller, which, as it moved away from the ulcer, gradually became flat, aligning with the skin. In patients with relatively fresh ulcers, the bottom was covered with necrotic masses.