Observation of fundus using a novel high‐speed and high resolution optical coherent tomography: a preliminary report

Abstract

AbstractPurpose to evaluate capability of femto‐second white laser in observing the fundus when applying it to optical coherent tomography (OCT) as a light source.Methods We have successfully developed 8 fs cw mode0locked Titanium Sapphire (TiS) laser which had broad band with ranging from 650 nm down to 950 nm. Using this laser, over 200 nm bandwidth portion ranging from 750 nm down to 950 nm pulse was created.. Acquistion time of one OCT image is o.o2 second and vertical resolution in the air is 2 μm in the air. Horizontal resolution is less than1 μm. High‐speed acquisition time allows us to observe time sequential OCT images like an OCT movie for one second using a computer soft ware. Fundus examination using this OCT system was performed in eyes of healthy volunteers and patients with age‐related macular degeneration (AMD) under approval of IRB. Effect of indocyanine green (ICG) in OCT images was also evaluated in the AMD patients when who has a routine ICG examination at clinic.Results Pulsative movement of choroidal vasculature and retinal vessels at the optic disc head could be observed in motion OCT images. Single scan OCT image of healthy macula delineated four distinctive lines in stead of three when observed with a conventional SD‐OCT, particularly in images scanned through extra fovea. Furthermore, as structure of the optic nerve head was clearly illustrated, so a manner of optic nerve how getting through the lamina cribrosa was well appreciated.Conclusion Femto‐second laser OCT is a promising tool to explore a new dimension of clinical ophthalmology particularly in examining AMD as well as glaucoma patients. Commercial interest