Abstract
We observed atherosclerotic plaque phantoms using a novel near-infrared (NIR) hyperspectral imaging (HSI) technique. Data were obtained through saline or blood layers to simulate an angioscopic environment for the phantom. For the study, we developed a NIR-HSI system with an NIR supercontinuum light source and mercury-cadmium-telluride camera. Apparent spectral absorbance was obtained at wavelengths of 1150 - 2400 nm. Hyperspectral images of lipid were constructed using a spectral angle mapper algorithm. Bovine fat covered with saline or blood was observed using hyperspectral images at a wavelength around 1200 nm. Our results show that NIR-HSI is a promising angioscopic technique with the potential to identify lipid-rich plaques without clamping and saline injection.
Highlights
Atherosclerosis is a disease in which plaque builds up inside the arterial wall
Bovine fat was observed through the blood layer only in the wavelength band around 1200 nm, but the image was blurry
Atherosclerotic plaque phantoms were observed through saline or blood layers with the NIR-hyperspectral imaging (HSI) system
Summary
Atherosclerosis is a disease in which plaque builds up inside the arterial wall. Many acute ischemic events result from the rupture of asymptomatic vulnerable plaques, which can cause thrombotic occlusion and myocardial infarction. Spectroscopic techniques are being applied, based on advances in spectroscopic photoacoustic imaging [10], fluorescence spectroscopy [11], Raman spectroscopy [12], and near-infrared (NIR) spectroscopy [13] [14]. Such methods can provide chemical information about the artery and plaque
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