Abstract
Primary lymphedema, orthostatic edema with increased ADH or aldosterone secretion, inappropriate ADH secretion associated with central nervous system, and/or thoracic pathology, congenital analbuminemia, severe nutritional deficiency with hypoproteinemia, protein-losing gastroenteropathies and hereditary angioneurotic edema have been discussed in the context of unusual and obscure clinical syndromes associated with edema. The pathogenetic mechanisms are not established in all cases, but major advances have been made in our understanding and clinical characterization of these entities. Consideration of these syndromes with documentation by appropriate laboratory studies can provide definitive diagnosis in many instances of clinically obscure edema.
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