Abstract
Sedentariness has been proposed as an independent risk factor for poor health. However, few studies have considered associations of sedentary time (ST) with physical functional health independent of time spent in moderate-to-vigorous physical activity (MVPA). Community-based men and women (n = 8623, 48-92 yr old) in the European Prospective Investigation of Cancer-Norfolk study attended a health examination for objective measurement of physical capability, including grip strength (Smedley dynamometer (kg)), usual walking speed (UWS (cm·s(-1))), and timed chair stand speed (TCSS (stands per minute)). Of these, 4051 participants wore an accelerometer (GT1M ActiGraph) for 7 d to estimate time spent in MVPA (MVPA, ≥1952 counts per minute) and ST (ST, <100 counts per minute). Relations between physical capability outcomes and both MVPA and ST were explored using linear regression. The mutual independence of associations was also tested, and ST-MVPA interactions were explored using fractional polynomial models to account for nonlinear associations. Men in the highest compared with those in the lowest sex-specific quartile of MVPA were stronger (1.84 kg; 95% confidence interval (CI), 0.79-2.89), had faster UWS (11.7 cm·s(-1); 95% CI, 8.4-15.1) and faster TCSS (2.35 stands per minute; 95% CI, 1.11-3.59) after multivariable adjustment. Similarly, women in the highest quartile of MVPA were stronger (2.47 kg; 95% CI, 1.79-3.14) and had faster UWS (15.5 cm·s(-1); 95% CI, 12.4-18.6) and faster TCSS (3.27 stands per minute; 95% CI, 2.19-4.25). Associations persisted after further adjustment for ST. Associations between higher ST and lower physical capability were also observed, but these were attenuated after accounting for MVPA. Furthermore, no MVPA-ST interactions were observed (Pinteractions > 0.05). More time spent in MVPA was associated with higher physical capability, but there were no independent ST associations.
Highlights
We examined whether interactions between sedentary time and moderate-to-vigorous physical activity (MVPA) were evident with respect to the outcomes considered
There was no evidence to suggest a threshold amount of MVPA below which more MVPA is not associated with higher physical capability; these data suggest the opposite effect, namely that increasing MVPA from Q1 to Q2, i.e., achieving greater than around 19 minIdj1, is associated with the greatest benefit for physical capability
Within the lowest quartile of MVPA, even 1 min more per day of MVPA was associated with higher physical capability
Summary
M. COOPER2, KATRIEN WIJNDAELE2, ROBERT LUBEN1, NICHOLAS J. WAREHAM2, SOREN BRAGE2, and KAY-TEE KHAW1 1Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UNITED KINGDOM; and 2MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Addenbrookes Biomedical Campus, Cambridge, UNITED KINGDOM
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