Abstract
284 Background: Clinician-assessed performance status (cPS) is prognostic in oncology. However, cPS may be limited by subconscious bias, and is confined to clinic visits. A more objective PS measure derived from cardiorespiratory fitness (VO2peak) and/or sensor-derived biometrics (activity (A), heart rate (HR), and activity/HR combinations (A/HR)) could better inform treatment selection, trial design, safety monitoring, and outcomes assessment. A multi-site study was conducted to examine the feasibility and utility of VO2peak and sensor-derived biometrics as complements to cPS and patient-reported PS (pPS). Methods: We enrolled 45 patients receiving chemotherapy at 4 institutions in 3 cohorts (solid tumor, hematologic malignancy, bone marrow transplant) to assess the feasibility and usefulness of VO2peak and sensor-derived biometrics. Patients underwent VO2peak prior to a cycle of treatment, wore a sensor for 4 weeks, and self-reported PS, physical function (PF), mental health (MH), and instrumental activities of daily living (IADLs). Sensor-derived variables included A, HR, and A/HR. Spearman’s rank correlations described bivariate relationships. Results: 70% of participants underwent VO2peak testing. 81% provided ≥ 2 weeks of sensor data. At baseline, VO2peak was moderately to strongly correlated with pPS and A/HR (r = 0.44-0.66, p < 0.05). pPS, but not cPS, was correlated with MH, PF, and IADLs (r = 0.58-0.69, p < 0.05). During treatment, pPS, PF, and IADLs were moderately to strongly correlated with A/HR (r > 0.4, p < 0.05). Conclusions: VO2peak testing and biometric sensor deployment were feasible within a multi-institutional setting of cancer patients receiving chemotherapy. Sensor-derived A/HR variables were correlated with underlying fitness, as well as patient-reported functioning throughout treatment. A/HR variables are candidates for further development and validation as digital biomarkers of performance status in cancer patients. Support: UG1CA189823; Clinicaltrials.gov Id: NCT02786628
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