Objective Evaluation of the Longevity of A Calcium Hydroxylapatite-Based Filler (Radiesse®)

Angelo-Khattar M

doi:10.16966/2576-2826.163

Abstract

Background: Calcium hydroxylapatite (CaHA) based soft-tissue filler (Radiesse® , Merz) is categorised as a biodegradable collagen-stimulating implant. It is comprised of a suspension of 25-45 micron diameter microspheres of CaHA(30%) in a carboxymethylcellulose (CMC) gel carrier (70%) and is one of the most well researched soft-tissue fillers. However, great discrepancies exist in the literature regarding the duration of clinical effect with the implant, ranging from only 6 to 24 months.

Highlights

Soft tissue fillers, originally developed for the filling of rhytids and folds, are currently used for the global restoration of facial volume and optimization of facial contours as in chin, tear trough, cheek, lip, and jawline correction
It is possible that the Calcium hydroxylapatite (CaHA) microspheres are degraded relatively swiftly in interstitial fluid and cannot sustain their biostimulating effect
The CaHA filler is injected onto the supra-periosteal plane in the malar area on both sides of the face, with a 22 G × 50 mm blunt-tipped cannula

Summary

Introduction

Originally developed for the filling of rhytids and folds, are currently used for the global restoration of facial volume and optimization of facial contours as in chin, tear trough, cheek, lip, and jawline correction. The hyaluronic acid filler’s longevity depends upon the extent of cross-linkage and the concentration and particle size of each product. These medical devices are replacement fillers and restore lost volume but do not induce long-term collagenstimulating effects [5,6]. Calcium hydroxylapatite (CaHA) based soft-tissue filler (Radiesse®, Merz) is categorised as a biodegradable collagen-stimulating implant. It is comprised of a suspension of 25-45 micron diameter microspheres of CaHA(30%) in a carboxymethylcellulose (CMC) gel carrier (70%) and is one of the most well researched soft-tissue fillers. Great discrepancies exist in the literature regarding the duration of clinical effect with the implant, ranging from only 6 to 24 months

Methods

Results

Discussion

Conclusion