Obezitenin Galanin ve Vaspin Düzeyleri ile İlişkisi

Abstract

Objective: Our aim was to compare vaspin and galanin in obese and normal weight individuals, to reveal whether these parameters are related to obesity and other related parameters. Material and Methods: Forty patients with obesity and 40 control subjects were included in the study. Biochemical parameters were recorded from patient’s files. Galanin and vaspin levels were studied from the sample obtained as a result of centrifugation of blood samples taken from the patients. Results: The groups were similar to each other in terms of gender and age (p>0.05). Galanine levels were higher in the group with obesity compared to the control group (p<0.001). Vaspin levels were higher in the group with obesity compared to the control group, but it was not statistically significant (p>0.05). Glucose, insulin, triglyceride and low-density lipoprotein cholesterol (LDL-C) levels were statistically significantly higher in the patient group than in the control group (p<0.001). There was no statistically significant difference in terms of thyroid stimulating hormone (TSH) (p>0.05). A statistically significant positive correlation was found with galanin, glucose, insulin, and body mass index (BMI), respectively (p<0.001, r=0.401; p <0.001, r=0.519; p <0.001, r=0.714). Also there was statistically significant positive correlation between vaspin and insulin, BMI, respectively (p=0.05, r=0.222; p=0.03, r=0.238). Conclusion: Our results show that high serum concentrations of galanin and vaspin in obese subjects may be the result of weight gain or may be one of many factors involved in the pathogenesis of obesity.