OBEZ HASTALARDA LEPTİN DÜZEYİNİN VE D VİTAMİNİ İLİŞKİSİNİN DEĞERLENDİRİLMESİ

Abstract

Introduction: Adipocyte-induced hormone leptin, nutrition and energy play an important role in homeostasis. Leptin regulates central or peripheral complex biological effects through its receptors. The mechanisms linking obesity and associated leptin resistance remain largely unclear. Also noncalcaemic effects of Vit D, perspective role is played on hormonal regulation of glucose metabolism and synthesis of adipokines by fat tissue. The aim of our study is to show the role of vitamin D levels on obesity and the activity of leptin levels during Vitamin D differentiation on obese patients. Material and Methods: 40 obese and healthy patients were included this research to analyze Vit D levels. While seen low-Vit D level in individuals, 4 weeks Vit D treatment has been completed. Whole experimental groups were taken blood for leptin measurement. Results: Our findings were indicated that leptin expression was decreased when vitamin D level in low. However, during vitamin D uptake, leptin levels in obese patients were increased correlated to deficiency. That means, leptin is known significant marker to detect obesity which has direct relation with Vitamin D level. Conclusion: These results highlight that reduction serum Vit D levels leads to improved leptin sensitivity. Future clinical trials should be tested Vit D alteration might be diagnostic factor for obesity treatment to leptin secretion.