Abstract
Left ventricular sub-epicardial strain was significantly lower in the obese mice with a 40% reduction in circumferential strain (p<0.001), a 19% reduction in longitudinal strain (p=0.03), and a 53% reduction in radial strain (p=0.06). By contrast, left ventricular sub-endocardial strain was modestly reduced in the obese mice in the circumferential direction by 12% (p=0.01), and not significantly different in the radial (p=0.63) or longitudinal (p=0.44) directions. Peak left ventricular torsion was reduced by 34% in the obese mice (p=0.06). Finally, the radial uniformity of strain index showed a reduction in the synchrony of contraction in the left ventricle (p=0.01) with a time delay in the septal to free wall direction.
Highlights
Obesity is an epidemic affecting over 1 in 3 adults in the United States
Diet-induced obesity leads to a reduction in cardiac contractility in mouse models as evidenced by reductions in left ventricular strains and torsion
Reductions in cardiac strain are mostly limited to the sub-epicardial layer of the left ventricle, with relative preservation of function
Summary
Obesity reduces left ventricular strains, torsion and synchrony in mouse models: a cine DENSE MRI study. Sage P Kramer1*, David Powell, Cassi Binkley, Lisa Cassis, Frederick H Epstein, Brandon K Fornwalt. From 16th Annual SCMR Scientific Sessions San Francisco, CA, USA. From 16th Annual SCMR Scientific Sessions San Francisco, CA, USA. 31 January - 3 February 2013
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