Obesity hypoventilation syndrome with chronic respiratory insufficency versus chronic obstructive pulmonary disease with obesity: Similar versus nonsimilar characteristics

Abstract

Obesity hypoventilation Syndrome (OHS) is diagnosed only after eliminating chronic obstructive pulmonary disease (COPD)and any other diagnostic ethiologies. The similar versus nonsimilar clinical and inflammatory laboratory parameters of OHS patients with chronic respiratory insuffiency compared to COPD patients with obesity are quite restrictive. In our study the answer to the question whether there is any other common point except obesity between OHS with respiratory insufficency and COPD with obesity is tried to be found. Method: OHS withpatients with chronic respiratory insufficency and COPD patients with obesity referred and followed by our ICU out patient clinic between 2014-2015 were included in retrospective cohort study.Demographic characteristics, BMI arterial blood gas analysis, spirometry, blood panel, biochemical parameters, CRP, values are all recorded.The two group of patients were compared according to their recorded data. Findings: 365 OHS and 378 COPD patinets were included totally in our study data.Inflammatory markers were insignificantly higher.Laboratory results that significantly higher had no clinical importance.COPD patients with obesity had significantly higher PCO2 values and insignificantly higher HCO3 levels.Spirometry results of OHS patients were in restrictive pattern. Results: Clinical presentation of COPD patients with obesity versus OHS patients looks like more or less the same where as the spirometric pattern is obstructive in COPD but restrictive in OHS.Coexistence of hypercapnia in OHS patient means that there is another underlying ethio pathology other than an airway pathology.