Abstract

The pathogenesis of obesity includes but not limited to genetic makeup, unbalance between intake and expenditure, proinflammatory cytokines and anti-inflammatory cytokines, obese and “anti-obese” hormones, and other causes. To lose weight, the best targets are these points. Fat distribution is determined by genetic makeup especially hormones. Too much obese hormones like steroid, estrogen and too less “anti-obese” hormones like endorphin, serotonin, dopamine, oxytocin, and testosterone is associated with fat deposit on the buttocks and thigh, namely “fat ass”, which appears an indicator for degree of homosexuality. Obesity is impacted by many factors. These factors include unhealthy lifestyle, metabolic factors, and unresolved frustrations etc. One biggest unresolved frustration is closeted sexual orientation especially homosexuality. Any sexual orientation is normal. Sexual orientation is X-linked and Y-linked traits, passing down from generation to generation. Homosexuality presents in different degree, some are stronger and some are lighter. The phenotype varies among different individuals, the manner, the behavior, the gesture, habit, likes, dislikes, and personalities. Gay marriage is granted in many states. Yet tradition is tradition does. Many folks still live in the dark, which causes lots of stress related work/school problems, smoking/alcohol/substance abuse, mental problems/psychiatric disorders, STDs, inequality for minorities, etc. Even progress had been made, LGBT healthcare is still on the way. Stress related issues, abuse, and mental problems can be managed positively, as well as with the recognition and acceptance by selves, family and friends, and “anti-obese” factors. STDs shall be better prevented with barrier protection and more disciplined sexual practice. Related information and education can be merged into smartphone app and into EMRS for regular visits. Team work among different society and community shall be strengthened. Above all, deal the reality with whole hearts, with love, with positive attitude. Smile, the world will smile at you. Start local, go global. Don’t ever shut the door.

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