OBESITY AND GYNECOLOGICAL MALIGNANCIES: A MULTI-CENTRIC CROSS SECTIONAL STUDY

Abstract

Introduction: Obesity is a growing problem and has signicant implications for a variety of diseases, including human cancers. Obesity has now become an epidemic so is the increase of gynecological malignancies in this era. So we review the association of obesity and gynecological malignancies like breast, endometrial, cervical, ovarian, tubal and Vulvo-vaginal carcinoma as an independent etiological risk factor. ToAims and objectives: estimate the prevalence of overweight and obese female in western Indian population. To nd the association of different gynecological malignancies and obesity. To evaluate the effect of obesity on different gynecological malignancies in accordance with age, reproductive life and socioeconomic status A cross sectional study in western. Materials and methods: Indian states Gujarat, Maharashtra and Rajasthan from January 2019 to December 2021, 10245 sample size and with overweight and obese post menarchal women up to 70 years of age with BMI >25 kg/m2 were compared to matched controls. All the consented subjects were initially screened by questionnaire by eld worker and examined for routine and advanced screening and examinations like Manual Palpation of breast, per abdomen, per speculum per vaginal examination and Pap smear by certied professionals according to standard protocols. Investigation was performed when required like mammography, Ultrasonography and laboratory investigations. Positive association of breast and endometrialResults: carcinoma especially in postmenopausal women and cervical carcinoma. Weak positive association for ovarian carcinoma only in premenopausal woman (not statistically signicant). We do not nd enough cases to conclude anything for vulvo vaginal and tubal carcinoma. Growing epidemic of obesity can be statistically correlated with increasingConclusion: incidence of gynecological malignancies like breast, endometrial, ovarian and cervical. Large scale studies further needed for evaluation of correlation of vulvo vaginal and tubal carcinomas.