Abstract
ObjectiveWe evaluated the association between obesity and ABO blood group antigens in a large sample of blood donors. MethodsThis cross-sectional study included 549,690 individuals who donated blood at three blood donation centers in Brazil between 2006 and 2012. Subjects were categorized by body mass index (BMI) as normal weight, overweight and obese. A multivariate analysis was performed by Ordinal Logistic Regression to evaluate associations between BMI and ABO blood group by gender and age. ResultsAmong the participants 37% were overweight and 15.3% were obese. The majority of participants were male (65.4%), less than 44 years old (86.6%) and had greater than 11 years of education (61.4%). Blood group O had the highest prevalence (48.9%) and group AB had the lowest prevalence (3.7%) among participants. The mean BMI was slightly above 25 kg/m2, the lower limit of an overweight classification in all ABO blood groups. Associations between specific ABO antigens and BMI were identified that differed according to gender. The O and B blood groups were associated with a greater prevalence of obesity in women and a lower prevalence in men. ConclusionsCarriage of specific alleles in the ABO blood group may differently influence BMI, according to gender.
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