Abstract
ABSTRACTObjectivesTo explore the prognostic value of obesity (measured by BMI) on RCC in a systemic inflammation state.Patients and MethodsClinicopathological and hematological data of 540 surgically treated Chinese localized RCC patients between 2005 and 2010 were retrospectively collected. Found by receiver operating characteristic (ROC) curve for cancer-specific survival (CSS), the optimal cutoff values of neutrophil-lymphocyte ratio (NLR, an indicator of systemic inflammation state) and BMI were 2.12 and 23.32, respectively. Survival curves were drawn using Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic value of BMI in localized RCC patients with different NLR.ResultsOverall, 36 patients died with a median follow-up of 70 months. Median overall survival (OS) was 66 months and the 5-year OS rate was 92.7%. In the multivariate analysis of total patients, higher BMI was an independent protective factor for CSS in total patients (p=0.048). While in systemic inflammation subgroup (high NLR subgroup) patients, higher BMI (obesity) turned out to be an independent protective factor for both CSS (p=0.025) and RFS (p=0.048).ConclusionIn localized RCC patients, obesity was an independent protective factor for CSS and RFS in a systemic inflammation state.
Highlights
Renal cell carcinoma (RCC) is the most common malignancy of kidney, accounting for 2%-3% of all adult malignancies [1]. 20%-40% of localized RCC patients still suffered from cancer recurrence or metastasis even after surgery treatment, despite the significant improvement of RCC therapy [2]
Cohort characteristics In total, 400 men and 140 women with localized RCC were included in the study with a mean age of 54±13.4 years old. 48.3% (261/540) of the tumors were located on the left side
No differences were found between reference group and high body mass index (BMI) group in terms of age, tumor laterality, cancer related symptoms presence, histology, tumor size, Fuhrman nuclear grade, tumor necrosis or neutrophil-lymphocyte ratio (NLR). 283 and 257 patients were respectively categorized into low and high NLR group, according to the cutoff value of NLR at 2.12 (Table-1)
Summary
Renal cell carcinoma (RCC) is the most common malignancy of kidney, accounting for 2%-3% of all adult malignancies [1]. 20%-40% of localized RCC patients still suffered from cancer recurrence or metastasis even after surgery treatment, despite the significant improvement of RCC therapy [2]. 20%-40% of localized RCC patients still suffered from cancer recurrence or metastasis even after surgery treatment, despite the significant improvement of RCC therapy [2]. It is of importance to find effective prognostic factors to facilitate progress in treatment strategy. Obesity is a widely accepted risk factor for the onset of RCC [3, 4]. As an indicator of obesity, body mass index (BMI) was widely studied for its effect on the prognosis of RCC. Obesity increases the incidence of RCC, several previous studies have shown that RCC patients with higher BMI at diagnosis might have better survival outcomes than those with normal or lower BMI levels [5,6,7].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International braz j urol : official journal of the Brazilian Society of Urology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
