Oat nutritious meal has beneficial effect on lipid metabolism in type 2 diabetes mellitus: A 3-month randomized controlled trial

Abstract

This study aims to evaluate the effects of oat nutritious meal (ONM) on the blood glucose and lipid metabolism in elderly patients with type 2 diabetes mellitus (T2DM). A randomized controlled trial (RCT) was conducted. Ninety-eight subjects were randomly divided into ONM group and control group. The ONM group was given 20 g ONM twice a day over a course of 3 months and the control group kept the diet as before. Glucose and lipids parameters were measured at baseline and once a month in the study. Repeated-measure analysis of variance was used for data analysis. We found that there were significant changes in the concentrations of fasting plasma glucose, 2-hour postprandial plasma glucose, 2-hour postprandial insulin, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c) and homeostasis model assessment for beta-cell function(HOMA-β) over time in both groups. For TC and LDL-c, the interaction between time and intervention was also significant, which indicated that the ONM intervention contributed to the reduction of TC and LDL-c levels compared to the control group during the follow-up (P = 0.026 for TC, P = 0.006 for LDL-c). Our research demonstrates that 40 g ONM/d reduces TC and LDL-c levels significantly. But it has no effect on the glucose metabolism in elderly patients with T2DM.