Oat attenuate non-alcoholic fatty liver and obesity via inhibiting lipogenesis in high fat-fed rat

Abstract

Obesity accompanied with metabolic disorder is often complicated by hepatic regulations of lipid metabolism and lipoprotein recruitment. Recent reports have suggested that oat has metabolic-regulating effect. In this study, we examined whether oat could improve obesity, body fat, serum parameters and liver lipid metabolism. In high-fat-diet (HFD)-fed rats, oat effectively reduced body weight and fat, and decreased food efficiency but not appetite. Oat lowered serum glucose, free-fatty-acid (FFA), triacylglycerol (TG), cholesterol, and LDL-C/HDL-C elevated by HFD, and dose-dependently reduced hepatic TG and cholesterol. Thirty percent oat markedly reduced lipid synthesis biomarkers FAS, GPAT and HMG CoA reductase, while 15% and 30% oat stimulated expressions of oxidation markers PPARα, CPT-1 and phosphorylated-AMPK. Oat increased LDL receptor, being beneficial for serum lipid-lowering. Thus, Oat could act as adjuvant therapeutics for metabolic disorders via attenuating obesity, body fat, and improving serum parameters with metabolic regulation and lipid clearance of liver.