Abstract
Online application for survival analysis (OASIS) has served as a popular and convenient platform for the statistical analysis of various survival data, particularly in the field of aging research. With the recent advances in the fields of aging research that deal with complex survival data, we noticed a need for updates to the current version of OASIS. Here, we report OASIS 2 (http://sbi.postech.ac.kr/oasis2), which provides extended statistical tools for survival data and an enhanced user interface. In particular, OASIS 2 enables the statistical comparison of maximal lifespans, which is potentially useful for determining key factors that limit the lifespan of a population. Furthermore, OASIS 2 provides statistical and graphical tools that compare values in different conditions and times. That feature is useful for comparing age-associated changes in physiological activities, which can be used as indicators of “healthspan.” We believe that OASIS 2 will serve as a standard platform for survival analysis with advanced and user-friendly statistical tools for experimental biologists in the field of aging research.
Highlights
The amount of lifespan data is increasing due to rapid growth in the field of aging research
The maximal lifespan is the upper percentile of the lifespan distribution, which contrasts with the mean lifespan [2]
This is of interest, because increasing the maximal lifespan can imply that an intervention is slowing the general processes of aging and not merely retarding the development of specific diseases [3]
Summary
The amount of lifespan data is increasing due to rapid growth in the field of aging research. Proper statistical analysis for dissecting the genetic and environmental factors associated with aging has become more crucial than ever before. We previously reported OASIS, a web service for survival analysis [1]. OASIS has become a popular online platform for experimental biologists in the field of aging research who need convenient access to statistical tools for the analysis of survival data including lifespan. After 5 years of extensive OASIS usage, it has become apparent that more features are required for the analysis of complex phenomena involved in aging. We report OASIS 2, which provides crucial updated features including advanced statistical analysis and an enhanced user-friendly interface
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