OA13.04 Prevalence of Molecular Alterations in NSCLC and Estimated Indoor Radon in Europe: RADON EUROPE Study

Abstract

There are geographical differences in the prevalence of driver oncogenic alterations in non-small cell lung cancer (NSCLC) around the world, potentially related to genetic and/or environmental factors. Radon is the leading cause of lung cancer in nonsmokers, in whom molecular driver alterations occur most commonly. We previously reported a potential correlation between the prevalence of certain drivers alterations in NSCLC and estimated radon risk in France (Mezquita et al, WCLC 2018). Here, we explore the correlation between estimated indoor radon exposure and the prevalence of driver alterations in NSCLC across European countries.