Abstract
Previous studies have demonstrated the prognostic role of the immunological tumor microenvironment in malignant pleural mesothelioma (MPM). Tumor-infiltrating macrophages form the major component of the leucocytes in MPM tumor microenvironment. Macrophages can be divided into two main phenotypes: type M1 macrophages have an anti-tumorigenic function and type M2 macrophages a pro-tumorigenic function promoting tumor development. The macrophage phenotypes affect the biological behavior of MPM and may provide potential therapeutic targets.
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