Abstract
Vascular hyperpermeability (leakage) facilitates tumor progression, metastasis, and limited delivery of therapeutics by fostering a hypoxic tumor microenvironment. Recently, pharmacological inhibition of vascular leakage enhanced tumor infiltration and activity of cytotoxic (CD8+) T-cells when used in combination with anti-PD1 blockade. However, the influence of vascular leakage on the tumor immune contexture and prognostic implications in human cancer patients remains to be investigated.
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