Abstract
Background CD4 cell depletion is central to HIV pathogenesis. However, CD4 cells present diverse lineages and the relative impact of HIV on Th17 and regulatory T cell (Treg) subsets remains unclear. CD161+ CD4 cells are a recently identified, gut-homing population with Th17 precursor potential. The balance between pro-inflammatory Th17 cells and immunoregulatory Tregs may be critical in HIV pathogenesis. This study addressed changes in CD161+, Th17 and Treg subsets during untreated HIV infection.
Highlights
CD4 cell depletion is central to HIV pathogenesis
The balance between pro-inflammatory Th17 cells and immunoregulatory Tregs may be critical in HIV pathogenesis
This study addressed changes in CD161+, Th17 and Treg subsets during untreated HIV infection
Summary
Address: 1Department of Paediatrics, University of Oxford, Oxford, UK, 2Royal Berkshire NHS Foundation Trust, Reading, UK, 3Northampton General Hospital, Northampton, UK and 4Wycombe Hospital, High Wycombe, UK. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):O19 doi:10.1186/1742-4690-6-S3-O19. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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