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Abstract
Background The conserved membrane-proximal external region (MPER) of HIV-1 envelope is a target for the rare broadly neutralizing 2F5, Z13 and 4E10 monoclonal antibodies (mAbs). However, MPER antibodies are rarely found in HIV-1 infected subjects nor arise following envelope immunization. A potential strategy to elicit such antibodies more frequently is to design an envelope protein with increased exposure of the 2F5 and 4E10 mAb epitopes.
Highlights
The conserved membrane-proximal external region (MPER) of HIV-1 envelope is a target for the rare broadly neutralizing 2F5, Z13 and 4E10 monoclonal antibodies
AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
MPER antibodies are rarely found in HIV-1 infected subjects nor arise following envelope immunization
Summary
HIV-1 gp envelope MPER mutation altered epitope conformation in lipid and increased sensitivity to 2F5 and 4E10 neutralizing antibodies. X Shen*, M Dennison, F Gao, DC Montefiori, L Verkoczy, B Haynes, M Alam and G Tomaras. Address: Duke University, Durham, NC, USA * Corresponding author from AIDS Vaccine 2009 Paris, France. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):O16 doi:10.1186/1742-4690-6-S3-O16. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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