OA trial bank

Abstract

Purpose: Based on small to moderate effect sizes for the wide range of symptomatic treatments in osteoarthritis (OA), and on the heterogeneity of OA patients, treatment guidelines for OA have stressed the need for research on clinical predictors of response to different treatments. Meta-analysis of individual patient data (IPD) of worldwide available RCTs would allow us to robustly identify subgroups that specifically response to certain treatment. The initiative to collect and analyze IPD in OA research is commenced by the OA Trial Bank, which is endorsed by the OARSI and the EULAR. The OA Trial Bank will bring together data from individuals with OA recruited to different clinical trials from different countries around the world to form a databank. Potential subgroups of patients for different interventions in OA patients will be predefined and will be analyzed with IPD. The procedures within the OA Trial Bank enable clinical OA researchers worldwide to initiate new research proposals and become involved in the OA Trial Bank. Methods: This workshop will inform about the OA Trial Bank organization, its legal procedures for data transfer, and the methods used for setting the objectives and performing data analyses. Secondly, the workshop will show an example based on the first IPD analyses from randomized trials studying the effect of intra-articular glucocorticoid injections in patients with hip or knee OA. Thirdly, by means of interactive procedures, subgroup identification for other interventions will be discussed and the workshop participants will learn how they can become involved in the OA Trail Bank.