Abstract
quartile range, and Receiver Operator Characteristic (ROC) curves. Results: Median PlGF concentrations in cases and controls were [Triage; 12 (IQR 12–15) v 256 (IQR 130–781) pg/ml, and Delfia; 38 (IQR 28–43) v 236 (IQR 161–419) pg/ml], respectively. The area under the ROC curve (AUC) for the diagnosis of early onset preeclampsia was 1.0 (95% CI, 1.0–1.0) for Triage and 0.97 (95% CI, 0.94–1.0) for Delfia. Conclusions: The Triage PlGF assay achieves greater separation of cases from controls. Further studies are needed to understand whether differences in analytical specificity (PlGF isoforms or complexed vs non-complexed PlGF) explain the lower levels of PlGF in preeclampsia for the Triage immunoassay.
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