O80 Neurophysiological prognosis in comatose patients after cardiac arrest: The italian multicentric study (PRONECA) – preliminary data-

Abstract

Objective To evaluate the prognostic value of EEG and SEPs association in post-anoxic comatose patients at different recording time from cardiac arrest (CA) a italian multicentric study. Methods Comatose patients after CA were included.EEG and SEPs were recorded within 12 h and at 72 h after CA. EEG was classified into “non-continuous” (low voltage, isoelectric, burst-suppression) and “continuous” (other patterns except epileptiform). SEPs were dichotomized into “bilaterally absent” (BA) and “present”. Outcome was evaluated at 6 months by GOS. “Recovery of consciousness” was considered good outcome. Results At the moment four center took part to the study and 230 patients were included. EEG and SEPs were recorded in 92 within 12 h in 102 at 72 h. “Continuous” EEG pattern at 12 h always predicted good outcome, “non-continuous” pattern at 72 h always predicted poor outcome. BA SEPs always predicted poor outcome. Early “continuous” EEG pattern was always associated with present SEPs. Conclusion EEG is a reliable time-dependent predictor of good outcome (within 12 h) and poor outcome (after 72 h). SEP is time-independent predictor of poor outcome. Early “continuous” EEG and BA SEPs are never associated together. Significance The combination of EEG/SEP findings allows prediction of good and poor outcome (within 12 h after CA) and of poor outcome (after 48–72 h). Recording of EEG and SEPs in the same patients allows always an increase in the number of cases correctly classified and an increase of the reliability of prognostication in a single patient due to concordance of patterns.