O62. Use of diuretics in the management of late-onset preeclampsia

Abstract

Introduction Hemodynamic examinations revealed high cardiac output (CO) in a portion of preeclamptic patients. These cases in our study population met the criteria for late-onset subtype of the disease as hypertension and proteinuria appeared beyond the 33rd gestational week. Objectives To decrease enormously high blood volume, as the possible reason for hypertension and edema, diuretics were applied in preeclamptic women with high CO, and edema. Methods After a short rest on the left lateral recumbent position, blood pressure (BP), and, by the use of impedance cardiography, CO and systemic vascular resistance (SVR) were determined. In the absence of relative hemoconcentration (hematocrit 37 l/l) 40 mg of furosemide was administrated orally in 10 cases. Examinations were repeated after 60 minutes of rest. Looking for the effects of the diuretics identical data (before and after furosemide medication) were compared by paired t -test. Significant difference was determined as p 0.05. Results In most of cases furosemide administration resulted in a lowering of CO and also BP. Heart rate and SVR remained stable, therefore change of CO was due to blood volume decrease. Download : Download full-size image Conclusion Our preliminary data draw attention to the possible use of diuretics in the management of late-onset preeclampsia and support the presumption that increased water retention may play a role in the development of hypertension in late-onset gestational hypertension or preeclampsia. Our data also suggest that the pathogenesis of late-onset preeclampsia is basically different from “classical” preeclampsia characterized by low CO. *The study was supported by TAMOP 4.2.2.D-15/1/KONV-2015-0004