O45-2 Association between agricultural exposures and pesticides and parkinson’s disease in the agrican (agriculture and cancer) french cohort

Abstract

Epidemiological studies have reported an increased risk of Parkinson’s disease (PD) in farmers, especially in those exposed to pesticides, but no clear conclusion can be drawn on the type of use, duration or latency associated with an effect. In the French prospective agricultural cohort AGRICAN, we assessed associations between agricultural and pesticide exposures, including their duration, and the risk of PD. Self-reported doctor-diagnosed PD and history of life-time exposure to 13 crops and 5 types of animals and pesticide use were collected at enrollment (2005–2011) among 181,842 participants affiliated to the French agriculture health assurance scheme (77% having worked on a farm, 23% who did not). Associations between agricultural/pesticide use and PD were estimated by logistic regression adjusted for sex, age, education, smoking status and alcohol consumption. PD was reported by 1 732 subjects (1.2%). Significant higher risk of PD was found for 3 types of animals (swine, horses, and poultry) and 7 crops (corn, peas, beet, rape, fruit-growing, potatoes and vegetables): odds ratios [OR] = 1.19 (horses) to 1.46 (peas). Pesticide exposure (E) was significantly associated with PD in all the animals and crops studied except tobacco (OR = 1.31 (cattle) to 1.83 (horses)) with a significant dose related-relationship with duration of exposure on cattle, swine, horses, poultry, vineyards and rape (P-trend