Abstract
The effects of class I, II, III and IV antiarrhythmic drugs (as classified by Vaughan Williams 1974), tetrodotoxin and β2-adrenoceptor antagonists on the extraneuronal accumulation of isoprenaline were examined in isolated rat hearts perfused with 3H-isoprenaline (1 μmol/l) and tropolone (100 μmol/l) for 30 min at a constant flow rate (6.5 ml/min) at 40°C. Quinidine (class I), verapamil (IV), diltiazem (IV), dilazep (IV), nifedipine (IV), tetrodotoxin and butoxamine, at a concentration of 10 μmol/l, significantly decreased the extraneuronal accumulation of isoprenaline.
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