Abstract
We have developed a multi-scale 3-D heart simulator “UT-Heart”, which reproduces the function of heart based on the molecular mechanisms of excitation-contraction coupling process. Combined with the personalization technology, of this simulator. we tested the capability of tailor-made heart model to reproduce the response to cardiac resynchronization therapy (CRT) in a retrospective study. We created heart models of nine patients treated by CRT based on the clinical data recorded before treatment. To each heart model, we performed CRT simulation according to the actual protocol and compared the results with clinical data. We found that simulated improvement in the maximum derivative of ventricular pressure can predict the clinically observed improvement in the ejection fraction. CRT simulation using tailor-made heart model can be a useful tool in clinical decision making.
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