O21. Resting-State Functional Connectivity, Cortical Gaba and Allopregnanolone in Postpartum Depression: A Functional Magnetic Imaging and Spectroscopy Study

Kristina Deligiannidis,Christina Fales,Aimee Kroll-Desrosiers,Scott Shaffer,Yanglan Tan,Janet Hall,Blaise Frederick,Elif Sikoglu,Richard Edden,Anthony Rothschild,Constance Moore

doi:10.1016/j.biopsych.2019.03.286

O21. Resting-State Functional Connectivity, Cortical Gaba and Allopregnanolone in Postpartum Depression: A Functional Magnetic Imaging and Spectroscopy Study

Kristina Deligiannidis, Christina Fales + Show 9 more

https://doi.org/10.1016/j.biopsych.2019.03.286

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Journal: Biological Psychiatry	Publication Date: May 1, 2019
Citations: 1

Affiliation: University of Massachusetts Chan Medical School, Zucker Hillside Hospital, Feinstein Institute for Medical Research, Johns Hopkins University, Harvard University, McLean Hospital, Imaging Center, National Institute of Environmental Health Sciences

#Abnormalities In Resting-state Functional Connectivity #Resting-state Functional Connectivity + Show 8 more

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Abstract

Postpartum depression (PPD) is associated with abnormalities in resting-state functional connectivity (RSFC) but the underlying neurochemistry is unknown. We hypothesized that the neuroactive steroid allopregnanolone (ALLO) is correlated to cortical GABA concentrations and RSFC in PPD as compared to healthy comparison women (HCW). We measured group RSFC with fMRI and pregenual anterior cingulate cortex (ACC) GABA+/Cr concentrations with magnetic resonance spectroscopy (MRS) and quantified peripartum ALLO using liquid chromatography/tandem mass spectrometry.

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