Abstract
Practice changes based on interpretation of the Surfactant, Positive Pressure, and Oxygenation Randomized Trial (SUPPORT), Canadian Oxygen Trial (COT), and Benefits of Oxygen Saturation Targeting (BOOST) II Trial stand to impact premature infants in every neonatal care unit around the world. How should we interpret the data? What practice changes should we make? Arguments for targeting higher saturations (91%-95%) have been made based on both the SUPPORT and BOOST II Trial. In contrast, results of COT demonstrate that targeting lower saturations (85%-90%) may be safe when alarm limits are strictly enforced.
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