O184: Predictive value of pre-treatment circulating inflammatory response markers in the neoadjuvant treatment of breast cancer: a systematic review and meta-analysis

Abstract

Abstract Purpose Systemic inflammatory response markers have been found to have a prognostic role in several cancers, but their value in predicting response to neoadjuvant chemotherapy is uncertain. A systematic review and meta-analysis of the literature was carried out to investigate this. Methods A systematic search of electronic databases was conducted to identify studies that explored the predictive value of circulating systemic inflammatory response markers in patients with breast cancer prior to commencing neoadjuvant therapy. A meta-analysis was undertaken for each inflammatory marker where three or more studies reported pathological complete response (pCR) rates in relation to the inflammatory marker. Outcome data were reported as odds ratios (ORs) using 95% confidence intervals (CIs). Results Forty-nine studies were included in total, of which 42 were suitable for meta-analysis. Lower pre-treatment neutrophil-lymphocyte-ratio (NLR) was associated with an increased rate of pCR (pooled OR 1.66, 95% CI 1.32 to 2.09; P<0.001). Lower white cell count (WCC) (OR 1.96, 95% CI 1.29 to 2.97, P=0.002) and lower monocyte count (OR 3.20, 95% CI 1.71 to 5.97) were also associated with pCR. Higher lymphocyte count was associated with increased pCR rate (OR 0.44, 95% CI 0.30 to 0.64, P<0.0001). Conclusion The present study found pre-treatment NLR, WCC, lymphocyte count and monocyte count of value in the prediction of pCR in the neoadjuvant treatment of breast cancer. However, further research is required to determine their value in specific breast cancer subtypes and to establish optimal cut-off values, prior to their adoption in clinical practice.