Abstract
Analysis of tissue renewal and regeneration depends critically on the availability of markers for prospective isolation of stem and progenitor cells. Using the monoclonal antibody GCTM-5, ee have identified a novel cell surface marker whose expression appears to be restricted to human tissues of endodermal origin. This large glycoconjugate is found on putative progenitor cells in the liver and the pancreas. The cells that express this marker in these tissues increase in numbers during tissue regeneration and repair, and in neoplastic transformation. In intestinal metaplasia of the esophagus, GCTM-5 marks cells that appear to be progenitors in the development of metaplasia. The pattern of GCTM-5 reactivity in this condition is consistent with a role for submucosal gland ducts as the origin of the metaplastic process. This marker will be useful in studies of embryonic stem cell differentiation and renewal, repair, and regeneration in tissues of endodermal origin.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
