Abstract

Novel treatments for refractory opioid use disorder (OUD) are needed given high treatment failure rates and associated overdose deaths. We initiated an FDA-approved and US National Institute on Drug Abuse (NIDA) sponsored clinical trial to evaluate the safety and feasibility of deep brain stimulation (DBS) of the Nucleus Accumbens (NAc) and ventral anterior internal capsule (VC) for treatment-refractory OUD.

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