O13. Microvascular and macrovascular hemodynamic effects of nicardipine in the treatment of severe pre-eclampsia

Abstract

(P = 0.008). aPWV was unaltered, even after adjustment for MAP (P = 0.6). Conclusion: This is the first study to investigate changes in AIx and PWV very early in pregnancy. We have demonstrated profound changes in brachial and central blood pressures and AIx within 2–3 weeks of conception, with no change in aPWV. Furthermore, late first trimester data cannot be used as ‘baseline’ data in order to identify the extent of cardiovascular adaptation in pregnancy as has been hitherto assumed.