Abstract
O.12 Isokinetic upper leg muscle strength as a functional parameter of nutritional status in patients with inflammatory bowel disease B. J. Geerling, R. W. StockbrElgger and R.-J. M. Brummer Dept of Gastroenterology, University Hospital Maastricht, Maastricht, The Netherlands. Introduction: Malnutrition is observed in patients with Inflammatory Bowel Disease (IBD). Functional parameters are often omitted in the assessment of nutritional status. The aim of this study was to assess the muscle strength as a functional parameter of nutritional status in IBD patients comprising Crohn's disease (CD) and ulcerative colitis (UC). Methods: In 37 IBD patients at time of diagnosis (IBD-new: 11CD, 26UC) age and sex matched with healthy controls and in 32 patients with longstanding CD in remission (CD-Iong) age and sex matched with healthy controls, muscle strength of the quadriceps and hamstrings was measured using an isokinetic dynamometer (Cybex II) with angular velocities of 60 and 180.s -~. Peak torques (PT's) and work capacities (WC) of muscle strength were determined. Fat-free mass (FFM) was assessed using Dual-energy X-ray absorptiometry. Paired t-tests were used for statistical analysis. Results: Hamstrings PT's (60, 180.s -1) were significantly reduced (P < 0.05) in CD-Iong (71.6 Nm __ 22.2 and 45.6 Nm _+ 15.2, respectively) compared with controls (87.6 Nm _+ 33.4 and 59.3 Nm + 31.9, respectively). WC of the hamstrings (180.s -1) was significantly decreased (P< 0.05) in CD-Iong (210.0J _+ 119.1) compared with controls (298.4J _+ 212.4). However, the PT's and WC of the quadriceps in CD-Iong were preserved compared to controls. The correlation between hamstrings PT's and FFM was significant (P < 0.001) in both IBD-new and the control-groups, but not in CD-Iong. Conclusion: Muscle strength of the hamstrings in patients with longstanding CD was significantly reduced while the strength of the quadriceps was preserved. Muscle strength was not decreased in IBD patients at time of diagnosis. The pathophysiology of the reduced muscle strength of the hamstrings needs to be elucidated.
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