O117. Role of some biomarkers in long term cardiovascular prognosis of pregnancy hypertensive disease

Abstract

Introduction There is growing evidence that preeclampsia (PE) is a risk factor for development of cardiovascular disease even before the menopause. Stratification of risk can be based not only in haemodynamic and anthropometric parameters, but also in intermediate phenotypes and functional genetic polimorphisms of pathogenic pathways in hypertension. Objectives To study the modulation, of some distant and intermediate phenotypes associated with hypertension in women with history of previous PE, by some genetic functional polimorphisms of pathways involved in the pathogenesis of those diseases. Methods A prospective study was done in a sample of 138 women (35.2 ± 5.48 years old), 90 of those presented PE 2–16 years ago. We evaluated demographic, anthropometric, haemodynamic and biochemical parameters: hsCRP, liver function tests, lipid profile, nitrites, nitrates and myeloperoxidase. Functional polymorphisms of some genes belonging to those pathways were determined by molecular biology techniques (PCR, PCR-RFLP). Statistical analyses were performed by parametric or non-parametric tests when appropriate. Results: Hypertension develops significantly (p 0.001) in 47,7% of women with history of PE compared with only 10.3% hypertensive women that did not have previous PE. Only some of the genotype carriers of those studied genes present already alterations in those parameters in normotensive women with history of previous PE compared with those without PE. Conclusions Some potential biomarkers including the genetic ones at different biological levels, of risk for the development of future cardiovascular diseases can be identified in women with previous PE.