O1-044 - High-Dose Etoposide as an Effective Mobilization Agent in NHL Previously Treated with CHOP ± RITUXIMAB

Abstract

ABSTRACT Background Etoposide is one of the effective mobilizing agents in non-Hodgkin's lymphoma (NHL), but safety and effectiveness of high-dose etoposide followed by G-CSF is not well defined. We conducted a retrospective study to evaluate the efficacy of high-dose etoposide plus G-CSF compared with other mobilizing agents in peripheral blood stem cell (PBSC) mobilization. Methods A total of 46 patients with NHL who were treated only with CHOP ± Rituximab and sequentially underwent PBSC mobilization between 2006 and 2011 were analyzed. Twenty-two patients received etoposide 500 mg/m2 at day 1, 2, 3 (VP16 group). Total 22 of other patients received ICE or DHAP or CHOP ± Rituximab and 2 patients received G-CSF only (others group). All patients administered G-CSF 10 µg/kg/day until apheresis completed. Chemotherapy-related toxic effects and PBSC mobilization results were compared between the groups. Results In the VP16 group, a median total CD34+ cells collected was 15.79 × 106 cells/kg, 77% of all patients having adequate (>2.0 × 106 cells/kg) CD34+ collections after first day of apheresis compared with a median in the others group of 4.1 × 106 cells/kg (P Conclusions High-dose etoposide improves the effectiveness of mobilization with more than three-fold higher stem cell yield compared with other mobilizing agents. Considering no mortalities in patients with neutropenic fever, high-dose etoposide plus G-CSF is a highly effective mobilizing agent with acceptable toxicity in patients with NHL who were previously treated with CHOP ± rituximab.