O-051 Impaired Endothelial Function In Adolescents With Type 1 Diabetes Or Overweight, Measured By Peripheral Artery Tonometry

Abstract

<h3>Background and aims</h3> Reactive hyperemia-peripheral artery tonometry (RH–PAT) is a non-invasive method for endothelial function assessment. The goal of this study is to investigate endothelial function as assessed with the RH-PAT in control adolescents and adolescents with type 1 diabetes (T1D) or overweight. <h3>Methods</h3> RH-PAT score and baseline pulse amplitude was measured after an overnight fast in 25 control subjects (age 12–20 years), 34 adolescents with T1D and 27 adolescents with overweight or obesity. <h3>Results</h3> RH-PAT score was lower in adolescents with T1D compared to healthy controls (1.6 [1.3–2.0] versus 1.9 [1.7–2.4], p = 0.0154). The same trend was seen in adolescents with overweight or obesity (1.5 [1.3–2.0] versus 1.9 [1.7–2.4], p = 0.027). Similarly, the baseline pulse amplitude was higher in the group of patients with T1D (373.0 [208.3–522.0] versus 145.3 [52.3–300.2], p = 0.0033) and in adolescents with overweight or obesity compared to healthy controls (416.3 [360.3–675.7] versus 145.3 [52.3­300.2], p &lt; 0.0001). Within the group with overweight, a significantly positive correlation was seen between baseline pulse amplitude and body mass index (BMI) standard deviation score (SDS) (<i>r = 0</i>.39 [0.006–0.67], p = 0.047). <h3>Conclusions</h3> Endothelial dysfunction, quantified by lower RH-PAT score or higher baseline pulse amplitude, was observed in both adolescents with T1D and with overweight. Early detection of vascular changes in these high-risk patient groups may allow targeted interventions to reduce cardiovascular disease in adulthood.