O036 Impact of Fetal Heart Maturity in Brain Development and later Neurocognitive Functioning in Adolescents with Congenital Heart Disease

Abstract

(copy:u¼165.000; p<0,001;memory:u¼204.000;p<0.001),Symbol Search(u¼1099.000; p¼0.004),BADS (u¼162.000;p<0.001), Stroop Test, words (u¼162.000; p<0.001), colors (u¼247.500; p<0.001), interference (u¼157.000; p<0.001) and Trail Making Test, A (u¼1426.500; p<0.001) and B (u¼1379.500; p<0.001). Several correlations were apparent between fetal/ neonatal parameters (mainly, the head circumference at birth) and neuropsycho- logical abilities in CHD. However, cyanosis and the Head circumference at birth stand as main correlations with cognitive development later on in CHD (R¼0.408;R 2 ¼0.167; F¼5.203;p¼0.009;HC:b¼0.256;t¼1.979;P¼0.053;Cyanosis:b¼-0.270;t¼-2.086; P¼0.042). Conclusion: Adolescents with CHD have worse neuropsychological performance than the control group, and the cyanotic worse than the acyanotic patients. The fetal anomalies in heart and circulation seem to have impact in delaying cerebral and somatic growth, pre- dicting cognitive impairment in adolescents with CHD. Disclosure of Interest: None Declared