O031 A systematic review and meta-analysis of the relationship between alcohol consumption and postoperative outcomes in gastrointestinal surgery

Abstract

Abstract Introduction Alcohol is a modifiable risk factor in patients having planned surgery and problematic drinking is an increasing problem. To date, no systematic review solely focuses on outcomes following gastrointestinal surgery and their relationship with alcohol use. This study aimed to summarize the evidence of the association between preoperative alcohol consumption and postoperative complications in gastrointestinal surgeries. Methods Comprehensive searches of MEDLINE, EMBASE, and Cochrane databases was undertaken to identify original studies investigating the association between preoperative alcohol consumption and postoperative complications occurring within 30 days of surgery. The primary outcome was 30-day mortality risk and secondary outcomes included postoperative complications such as surgical site infections and risk of anastomotic leak. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a random effects model. Results In total, 3182 reports were identified and reviewed for eligibility, and data was extracted from 26 studies that met inclusion criteria. 14 studies were included in the meta-analysis. Clearly defined high preoperative alcohol consumption was associated with an increased risk of 30-day mortality (Odds ratio (OR)=1.56; 95% confidence interval (CI):1.07–2.28). High alcohol intake was also associated with an increased risk of anastomotic leak following colorectal surgery (OR 2.17 (95% CI: 1.74–2.72) and an increase in risk of surgical site infections (OR=1.32; 95% CI: 1.15- 1.53). Conclusion Preoperative alcohol consumption was associated with an increased risk of 30-day mortality, risk of anastomotic leakage and surgical site infections. Preoperative modulation of alcohol intake may influence post-operative complications after gastrointestinal surgery.