Abstract
Background Recent experimental evidence points out a possible involvement of outer and inner retinal layers in hypersensitivity of migraine patients to light stimuli. To investigate the short-wavelength-sensitive (S) and the medium/longwavelength-sensitive (ML) cone photoreceptors of the visual pathways in migraine without aura (MO) patients between attacks and in healthy volunteers (HV) by using yellow-blue (Y-B) or red-blue (R-B) visual flicker stimuli.
Highlights
Recent experimental evidence points out a possible involvement of outer and inner retinal layers in hypersensitivity of migraine patients to light stimuli
Fourier analysis allowed extracting from the focal electroretinograms (FERGs) data the fundamental (1F) and the second harmonic (2F) components that are related respectively to outer and inner retinal activity
Phase, 1F R-B phase (r = 0.521, p = 0.03), 2F Y-B amplitude, habituation slope (r = 0.686, p < 0.01), and 2F R-B phase (r = 0.526, p = 0.03). These results suggest that an abnormal signal transduction from the outer to the inner retinal layers could contribute to the mechanisms by which light causes pain or discomfort during the migraine headache
Summary
An abnormal transduction of the chromatic stimuli from the outer to the inner retinal layers may contribute to cause photophobia in migraine. Gianluca Coppola1*, Luisella Corso, Antonio Di Renzo, Antonello Fadda, Francesco Martelli, Cherubino Di Lorenzo, Vincenzo Parisi, Jean Schoenen, Benedetto Falsini, Francesco Pierelli. From Abstracts from the 1st Joint ANIRCEF-SISC Congress Rome, Italy. From Abstracts from the 1st Joint ANIRCEF-SISC Congress Rome, Italy. 29-31 October 2015
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