Abstract
The enhanced cardiac sympathetic afferent reflex (CSAR), a sympatho-excitatory reflex originating in the heart, contributes to elevated sympathetic tone as well as cardiac remodeling in chronic heart failure (CHF). The molecular and cellular mechanisms underlying cardiac spinal afferent sensitization are not fully understood. We hypothesized that chronic macrophage activation in the thoracic dorsal root ganglia (DRG) sensitizes cardiac spinal afferents via suppression of voltage-gated potassium (Kv) channels in CHF.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Neuromodulation: Technology at the Neural Interface
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
