Abstract
Results: Infrequent intrahepatic total HBVDNA (2/22, 9.1%) and cccDNA (1/22, 4.5%) were detected in biopsies; HBsAg and HBcAg IHC staining was negative. HBV-specific T cell responses were similar between “anti-HBc alone” individuals and HBV resolvers (Figure 1). Circulating HBV-memory B cell responses were detected in all “anti-HBc alone” individuals, consistent with an HBsAgspecific memory pool. After one HBV vaccine dose, increased antiHBs antibody levels were observed, accompanied by an expansion of HBsAg-specific memory B cells (P =0.0226) (Figure 2). Conclusions: “Anti-HBc alone” individuals showed HBV-specific T cell and memory B cell responses typical of previous viral exposure and protective memory, suggesting a resolved infection.
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