Abstract
Local neuromodulation of brain functions can be accomplished in many ways: electrical stimulation, local micro-infusion of drugs, implantations of viruses or engineered cells, etc. We have studied targeted encapsulated cell implants delivering active substances locally in Alzheimer patients (AD). AD is associated with early loss of basal forebrain cholinergic neurons (BFCNs) and cognitive dysfunction. BFCNs are dependent on nerve growth factor (NGF). Previously, we have developed an encapsulated cell biodelivery (ECB) platform and utilized it to stimulate BFCNs in two cholinergic target sites (Ch4 [nucl.
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